Scholarly Article
The Relationship of Blood Glucose with Early Morbidity, Mortality, and Other Prognostic Factors in Pancreatic Cancer
Ozer, Bahri, Bolat, Ferdi, Keyif, Fatih, Peltek Ozer, Songul, Sit, Mustafa, Karagoz, Ibrahim, Aktas, Gulali
2025-06-25 · Advances in Modern Biomedicine · Cultech Publishing Sdn. Bhd.
Abstract
Aim: Pancreatic cancer remains a major global health issue due to its high morbidity rate and aggressive course. The relationship between diabetes and pancreatic cancer exhibits a bidirectional nature. Elevated blood glucose levels and insulin resistance may create a favorable microenvironment for cancer development. In our study, we aimed to investigate the relationship between preoperative blood glucose levels and morbidity, mortality, and prognostic factors in pancreatic cancer. Methods: Patients were classified into two groups: those with preoperative elevated glucose levels (>126 mg/dL) and those with normal glucose levels (≤125 mg/dL). The parameters analyzed included gender, age, postoperative drain amylase levels, length of hospital stay, morbidity, mortality, tumor size, and the number of metastatic lymph nodes. Results: A total of 86 patients were included in the study. In predicting early postoperative mortality, age, tumor size, lymph node count, and preoperative glucose levels were not statistically significant (p=0.16, 0.84, 0.81, 0.43, respectively). However, morbidity, drain amylase levels, and hospital stay duration were statistically significant (p=0.001, 0.005, 0.004, respectively). ROC analysis revealed that hospital stay duration of more than 11 days had a sensitivity of 92% and a specificity of 58% for predicting mortality. Conclusion: Present study showed that hospitalization duration and postoperative amylase levels were strongly associated with patient outcome in subjects with pancreas cancer. Proactive identification and management of these factors are essential to enhance postoperative outcomes and reduce mortality risks in this patient population.
Keywords
Pancreatic cancer, Blood glucose, Diabetes, Hospitalization, Mortality
Citation Details
Advances in Modern Biomedicine, pp. 11-20